- Provides fungal and bacterial proteases to hydrolyze difficult-to digest proline-containing peptides such as gluten and casein
- Provides wide spectrum carbohydrate digestion with plant-based papain, bromelain, and fungal digestive enzymes
- High potency formulation allows for easy dosing, with nearly 300 mg enzyme blend delivered in each vegetarian capsule
- Completely suitable for vegetarians and vegans
Digest-ProGD® HP is a high potency proprietary enzyme blend, providing fungal proteases derived from Aspergillus oryzae, bacterial protease derived from Bacillus subtilis, as well as comprehensive carbohydrate digestive support from papain, bromelain, and fungal digestive enzymes. Aspergillus oryzae extracts are rich in prolyl endopeptidases as well as dipeptidyl peptidase IV (DPP-IV) – a multifunctional serine protease which targets proline containing peptides, such as those found in both gliadin and casein, both proteolytically resistant proteins.1-3
Indeed, protease activity from Aspergillus oryzae targets the proline-rich 33-mer of gliadin, perhaps the most immunotoxic peptide derived from gliadin.4 The antigenic and immunomodulatory proline-rich proteins found in gluten are thought to trigger an inflammatory response in patients with either celiac disease or gluten sensitivity, often due to inadvertent gluten exposure, even for those on a gluten free diet.5 Supplementation with protease from Aspergillus oryzae has also been linked to a bifidogenic effect in animals, suggesting a potential probiotic effect.6
In addition to fungal and bacterial proteases, Digest-ProGD® HP provides alpha-amylase, cellulose, and hemicellulose activity for comprehensive carbohydrate digestion support.